V.B. Rosa1, B.C.V. Campos1, A. Schuffner1
1Conceber Centro de Medicina Reprodutiva – Curitiba, PR
Objective: The objective of this study was to retrospectively evaluate blastocyst formation and pregnancy rate in different age groups.
Methods: Between 2012 and 2015, 363 fresh-cycle patients with oocytes and their own semen, without PGT-A, were divided into 3 groups (?34a, 35 to 39a and ?40a), comparing the results obtained when embryos were transferred at cleavage stage or blastocyst. The following rates were compared: Blastocyst formation x age group; blastocyst culture x age group and clinical pregnancy x embryonic development by age group. For the statistical analysis we used Fisher’s exact test.
Results: The rate of blastocyst formation for the groups “?34a”, “35 to 39a” and “?40a” was 30.5, 21.3 and 0% respectively. 71.4% of the patients who obtained blastocyst were up to 34 years old, while 28.6% were patients between the ages of 35 and 39 years. Blastocysts were not obtained in patients over 40 years of age. Blastocyst transfer results significantly in more clinical pregnancies when compared to embryos at the cleavage stage, regardless of the age range (61.4 and 35.3%) ?34a (38.5 and 15.9%) from 35 to 39a and (0 and 10%) ?40a, respectively.
Conclusion: Transfer of embryos at the blastocyst stage showed better pregnancy outcomes when compared to embryos at the cleavage stage. Collaborating with the literature, the younger the patient, the higher the rate of blastocyst formation.